Signaling in the immune response.
نویسنده
چکیده
Many pathogens that can infect C. elegans have been described, including some that co-exist with the nematode in its natural environment. This chapter describes our current understanding of the different innate immune responses of C. elegans that follow infection. It focuses on the main signalling pathways that have been identified and highlights the inclusion of certain molecular cassettes in both immune and developmental functions.
منابع مشابه
Prediction of MicroRNAs bind to Toll-like Receptors Pathway in Chicken based on Bioinformatics Method
Background: Toll-like receptors (TLRs) detect diverse pathogen-associated molecular patterns and play a critical role in the innate immune response. Hosts should activate TLR-signaling pathways to eliminate invading pathogens. However, excessive activation of these pathways may interrupt immune homeostasis, leading to several diseases. Therefore precise regulation of TLR-signaling pathways is e...
متن کاملThe role of microRNAs and phytohormones in plant immune system
The plant-pathogen interaction is a multifactor process that may lead to resistance or susceptible responses of plant to pathogens. During the arms race between plant and pathogens, various biochemical, molecular and physiological events are triggered in plant cells such as ROS signaling, hormone activation and gene expression reprogramming. In plants, microRNAs (miRNAs) are key post-transcript...
متن کاملDifferential genes expression analysis of invasive aspergillosis: a bioinformatics study based on mRNA/microRNA
Invasive aspergillosis is a severe opportunistic infection with high mortality in immunocompromised patients. Recently, the roles of microRNAs have been taken into consideration in the immune system and inflammatory responses. Using bioinformatics approaches, we aimed to study the microRNAs related to invasive aspergillosis to understand the molecular pathways involved in the disease pathogenes...
متن کاملP-246: Gene Variation of TLR4 in Patients with Endometriosis
Background: Endometriosis, defined as the presence of endometrial tissue outside of the uterus, is an estrogen-dependent chronic inflammatory condition associated with degrees of pelvic pain and infertility. Toll-like receptors play a key role in immune response, by regulating inflammatory reactions and activating adaptive immune response to eliminate infectious pathogens and cancer debris. Pol...
متن کاملRecent Advances in T Cell Signaling in Aging
The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملThe Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- WormBook : the online review of C. elegans biology
دوره شماره
صفحات -
تاریخ انتشار 2006